银河

华娟，副教授，硕士研究生导师。主要从事导致男性不育的遗传学因素及环境因素的分子机制。主持国家自然科学基金，安徽省自然科学基金青年基金、安徽省高校科研计划重点项目和银河 基础与临床合作等基金。以第一或通讯作者发表学术论文十余篇，包括Human Molecular Genetics、Andrology、Asian J Androl、Reproductive Biology and Endocrinology等国际学术杂志。

教育经历

1.2009.7–2013.6    中国科学技术大学, 遗传学, 博士

2.2007.9–2009.6    中国科学技术大学, 遗传学, 硕士直接攻读博士

工作经历

2024.01-至今         银河 ，银河 生化教研室，副教授

2013.08-2023.12   银河 ，银河 生化教研室，讲师（校聘副教授）

1. 国家自然科学基金-面上项目，TBCD调控精原细胞分化与减数分裂启动介导非梗阻性无精子症的分子机制研究，主持；

2. 国家自然科学基金-青年项目，中心粒蛋白POC1B纯合移码突变导致少弱畸精子症的分子机制研究，主持；

3. 安徽省高校科研计划重点项目，联合代谢组学和蛋白组学探索线粒体动力学失衡在低氧诱导的雄性大鼠睾丸损伤中的作用及机制，2024.10-2026.10，主持；

4.银河 基础与临床合作研究提升计划，2020xkjT014，WDR12纯合错义突变导致锥形头部精子的分子机制研究， 2021.01-2023.12，主持；

5.安徽省自然科学基金青年项目，1608085QH174，SOD1调节原始卵泡形成的分子机制，2016.06-2018.06，主持。

1. Xin Chen, Wenjing Liu, Jingtian Shi, Zhaoyu Chen, Mingliang Han, Hui Jiang, Xiansheng Zhang, Yangyang Wan, Juan Hua. Ameliorative effects of coenzyme Q10 against hypoxia-induced and varicocele-associated spermatogenesis dysfunction in rat.Andrology. 2026 Mar;14(3):796-808.

2. Yangyang Wan*, Zhu Wen*, Wenjing Liu, Xiaohua Jiang, Limin Wu, Hui Jiang, Xiansheng Zhang^#, Qinghua Shi^#, Juan Hua^#. High-risk of low birth weight in couples with advanced paternal age in IVF treatment. Andrology. 2024. doi.org/10.1111/andr.13745. 

3. Yangyang Wan^*, Xiaoyun Shi^*, Wenjing Liu, Shun Bai, Xin Chen, Siyao Li, Xiaohua Jiang, Limin Wu, Xiansheng Zhang^#, Juan Hua^#. Associations of Ureaplasma urealyticum infection with male infertility and IUI outcomes. Asian J Androl. 2024

4. Juan Hua^#, Bo Xu^#, Wenjing Liu, JingTian Shi, Hui Jiang, XiaoJun Zha^*, Xiansheng Zhang^*, Yangyang Wan^*. Homozygous frameshift variant in POC1B cause male infertility with oligoasthenoteratozoospermia in human and mice. Hum Mol Genet. 2023 Apr 18;ddad061. doi: 10.1093/hmg/ddad061. 

5. Yang-Yang Wan^#, Wenjing Liu, Bo Xu*, Xiaohua Jiang*, Juan Hua*. Association of paternal MTHFR polymorphisms (C677T) with clinical outcomes in ICSI treatment. Frontiers in Endocrinology, 2022 Dec 22;13:1084463.

6. Juan Hua^#, Lan Guo, Yao Yao, Wen Hu, Yang-Yang Wan, Bo Xu. Biallelic mutations in WDR12 are associated with male infertility with tapered-head sperm. Asian J Androl. 2022 Sep 30. doi: 10.4103/aja202269.

7. Yao Yao^#, Yangyang Wan^#, Xiaoyun Shi^#, Lan Guo, Hui Jiang; Xiansheng Zhang, Bo Xu*, Juan Hua*. Letrozole protects against cadmium-induced inhibition of spermatogenesis via LHCGR and Hsd3b6 to activate testosterone synthesis in mice. Reproductive Biology and Endocrinology, 2022, 20(1).

8. Yang-Yang Wan^#, Lan Guo, Yao Yao, Xiao-Yun Shi, Hui Jiang, Bo Xu, Juan Hua*, Xian-Sheng Zhang*. MBOAT1 homozygous missense variant causes nonobstructive azoospermia. Asian Journal of Andrology, 2022, 24(2): 186–190.

9. Juan Hua^#, Yang-yang Wan*. Whole-exome sequencing identified a novel mutation of AURKC in a Chinese family with macrozoospermia. Journal of Assisted Reproduction and Genetics, 2019, 36(3): 529-534.

10. Hua J^#, Xu B, Yang Y, Ban R, Iqbal F, Cooke HJ, Zhang Y, Shi Q. Follicle Online: an integrated database of follicle assembly, development and ovulation. Database (Oxford).2015 Apr 29; 2015: bav036.

1. 2022年荣获银河 復元科技新星称号；